Updating evidence role corticosteroids severe sepsis septic shock

Assessment for risk of bias was carried out by the authors of the Cochrane review in accordance with the Cochrane Handbook for Systematic Reviews of Interventions [9].

Full details are available within the original analysis [2].

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Network plots were created for each outcome to illustrate which interventions had been directly compared within trials.

The thickness of the nodes and edges in each network is proportional to the number of patients allocated to each intervention and contributing to each pairwise comparison, respectively.

These questions have been investigated primarily in those patients with septic shock, and sufficient studies have been conducted to allow multiple meta-analyses [2–4], including a recently updated Cochrane review [2].

However, not all therapeutic corticosteroids are the same.