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When asked in a 2001 interview on Larry King Live what her father's source of income was, Heche replied, "Well, he was a choir director. He said that he was involved in a business of gas and oil. But he never was involved in the business of gas and oil ever." On March 3, 1983, when Heche was 13, her 45-year-old father died of AIDS. Heche flew to New York City, auditioned, and was offered a job, but her mother insisted she finish high school first.
Although he never came out as homosexual, "He was in complete denial until the day he died. Shortly before her high school graduation in 1987, Heche was offered a dual role on the daytime soap opera Another World. My mother was very religious and maybe she thought it was a sinner’s world," Heche stated.
Premiered at the 2001 Toronto International Film Festival, the film received a DVD release in 2005.
She appeared as a hospital administrator in the thriller John Q, about a father and husband (Denzel Washington) whose son is diagnosed with an enlarged heart.
In 1996, Heche landed her first substantial role as a college student contemplating an abortion in a segment of the made-for-HBO anthology film If These Walls Could Talk, co-starring Cher and Demi Moore.
Also in the year, she appeared opposite Catherine Keener portraying childhood best friends in the independent film Walking and Talking.
Her Catherine is a case of arrested development, impatient, aggressively indignant, impulsive".
In 2004, Heche received a Primetime Emmy Award nomination for Best Supporting Actress for her performance in the Lifetime movie Gracie's Choice, as well as a Saturn Award nomination for Best Actress for her performance in the CBS television film The Dead Will Tell.
Psycho earned mediocre reviews, and despite a US million budget, it made a lukewarm US.1 million worldwide.
In the same year, she acted opposite Alec Baldwin in Broadway's Twentieth Century, about a successful and egomaniacal Broadway director (Baldwin), who has transformed a chorus girl (Heche) into a leading lady.
For her performance, she was nominated for the 2004 Tony Award for Best Actress in a Play.
In 1998, Heche portrayed Marion Crane in Gus Van Sant's horror remake Psycho.
A highly publicized relationship with comedian Ellen De Generes was followed by a significant downturn in Heche's career, although she has continued to act, appearing in the well-received independent films Birth (2004), Spread (2009), Cedar Rapids (2011), Rampart (2011), and Catfight (2016).